Gating-like Motions and Wall Porosity in a DNA Nanopore Scaffold Revealed by Molecular Simulations

Maingi, V., M. Lelimousin, S. Howorka, M. Sansom

ACS Nano, 9(11): 11209–11217 (2015)

A Training Program to Improve the Interdisciplinary Breadth and Depth of your Research Group

P. Lukeman, S. Howorka 

Nat Nanotechnol, 10(11): 992 (2015)

Molecular and Thermodynamic Factors Explain the Passivation Properties of Poly(ethylene glycol)-Coated Substrate Surfaces against Fluorophore-Labeled DNA Oligonucleotides 

Ren, C., R. Schlapak, R. Hager, I. Szleifer, S. Howorka 

Langmuir, 31(42): 11491–11501 (2015) 

Dendrimers in Nanoscale Confinement: The Interplay between Conformational Change and Nanopore Entrance

Ficici, E., I. Andricioaei, S. Howorka 

Nano Lett, 5(7): 4822-4828 (2015)

Nanopore-Based Electrical and Label-Free Sensing of  Enzyme Activity in Blood Serum

Kukwikila, M., S. Howorka

Anal Chem, 87(18): 9149–9154 (2015)

Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State

Seifert, A., K. Göpfrich, J. R. Burns, N.Fertig, U.F. Keyser, S. Howorka

ACS Nano, 9(2): 1117-1126, Cover (2015)

S-layer Structure in Bacteria and Archaea

C. Madhurantakam, S. Howorka, H. Remaut 

In: Nanomicrobiology L. L. Barton et al. (eds.), Springer Science+ Business Media New York, 11-37 (2014)

Membrane-Spanning DNA Nanopores with Cytotoxic Effect 

Burns, J. R., N. Al-Juffali, S. M. Janes, S. Howorka

Angew Chem Int Ed 53(46): 12466-12470 (2014)

DNA-Modified Polymer Pores Allow pH and Voltage-Gated Control of Channel Flux

S. Buchsbaum, G. Nguyen, S. Howorka, Z. Siwy

J Am Chem Soc, 136(28): 9902-9905 (2014)

Involvement of SbsB in Ca2+ Triggered S-Layer Assembly

C. Madhurantakam, S. Howorka, H. Remaut (2014) 

Encyclopedia of Inorganic and Bioinorganic Chemistry, John Wiley & Sons, 2-8.

Structure and Mechanism of the Bacterial Protein Secretion Channel CsgG

Goyal, P., P. V. Krasteva, N. Van Gerven, F. Gubellini, I. Van den Broeck, A. Troupiotis-Tsaïlaki, W. Jonckheere, G. Péhau-Arnaudet, J. S. Pinkner, M. R. Chapman, S. J. Hultgren, S. Howorka, R. Fronzes, H. Remaut 

Nature, 516(7530): 250-253 (2014)

Microarrays and Single Molecules: An Exciting Combination

S. Howorka, J. Hesse 

Soft Matter, 10(7): 931–941 (2014)

Lipid Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor

Burns, J. R., K. Göpfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser, S. Howorka

Angew Chem Int Ed, 52(46): 12069–12072 (2013)

Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

Buchsbaum, S., N. Mitchell, M. Hugh, M. Wiggin, A. Marziali, P. V. Coveney, S. Ziwy, S. Howorka

Nano Lett, 13(8): 3890–3896 (2013)

Self-Assembled DNA Nanopores that Span Lipid Bilayers

Burns, J., Stulz, E., S. Howorka 

Nano Lett, 13(6): 2351-2356 (2013)

DNA Nanoarchitectonics: Assembled DNA at Interfaces

S. Howorka  

Langmuir, invited review, 29(24):7344-7353. Cover. (2013)

Nanopores as Protein Sensors

S. Howorka, Z. Siwy

Nat Biotechnol, 30(6), 507-508 (2012)

SbsB Structure and Lattice Reconstruction Unveil Ca2+ Triggered S-layer Assembly

Baranova, E., Fronzes, R., Garcia-Pino, A., Papapostolou, D., Péhau-Arnaudet, G., Pardon, E., Steyaert, S., Howorka, S., Remaut, H.

Nature, 487(405): 119-122 (2012)

Painting with Biomolecules at the Nanoscale: Biofunctionalization with Tunable Surface Densities

Schlapak, R., Danzberger, J., Haselgruebler, T., Hinterdorfer, P., Schäffler, F., Howorka, S. 

Nano Lett, 12(4), 1983–1989 (2012)

Microarrays and Single Molecules: An Exciting Combination

S. Howorka, J. Hesse 

Soft Matter, 10(7): 931–941 (2014)

Nanoscale DNA Tetrahedra Improve Biomolecular Recognition on Patterned Surfaces

Schlapak, R., J. Danzberger, D. Armitage, D. Morgan, P. D. Pollheimer, H. J. Gruber, F. Schäffler, S. Howorka 

Small, 8(1): 89-97 (2012)

Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra

Leitner, M., N. Mitchell, M. Kastner, R. Schlapak, H. J. Gruber, P. Hinterdorfer, S. Howorka, A. Ebner 

ACS Nano, 5(9): 7048-7054 (2011)

The structure of Bacterial S-layer Proteins

Pavkov-Keller, T., S. Howorka, W. Keller 

In: Molecular Assembly in Natural and Engineered Systems, Series title: Progress in Molecular Biology and Translational Science, Academic Press, Editor: S. Howorka: 73-130 (2011)

Rationally Engineering Natural Protein Assemblies in Nanobiotechnology 

S. Howorka

Curr Opin Biotechnol, 22: 485-491 (2011)

Nanoimaging, Molecular Interaction, and Nanotemplating of Human Rhinovirus Nanopores

Kastner, M., C. Rankl, A. Ebner, P. D. Pollheimer, S. Howorka, H. J. Gruber, D. Blaas, P. Hinterdorfer 

In: Scanning Probe Microscopy in Nanoscience and Nanotechnology, Vol.2., Editor, B. Bhushan, Springer-Verlag, Heidelberg (2011)

DNA Strands Attached Inside Single Conical Nanopores: Ionic Pore Characteristics and Insight into DNA Biophysics

Nguyen, G., S. Howorka, Z. S. Siwy 

J Membr Biol, 239(1-2): 105-13 (2011)

Improved Kelvin Probe Force Microscopy for Imaging Individual DNA Molecules on Insulating Surfaces

Carl Leung, Dario Maradan, Armin Kramer, Stefan Howorka, Patrick Mesquida and Bart W Hoogenboom 

Appl Phys Lett, 97, 203703 (2010)

Biosensors and Biofuel Cells with Engineered Proteins

Caruana, D. J., S. Howorka

Mol Biosyst, 6(8): 1548 - 1556 (2010)

Nanomechanical Recognition Measurements of Individual DNA Molecules Reveals Epigenetic Methylation Patterns

Zhu, R., S. Howorka, J. Pröll, F. Kienberger, J. Preiner, J. Hesse, A. Ebner, V. P. Pastushenko, H. J. Gruber, P. Hinterdorfer

Nature Nanotechnol, 5(11): 788-791 (2010)

Interfacial Dipole Dynamics of Light-Emitting Diodes Incorporating a Poly(amidoamine) Dendrimer Monolayer

Winroth, G., O. Fenwick, M. A. Scott, D. Yip, S. Howorka, F. Cacialli 

Appl Phys Lett, 97(4): 043304 (2010)  

Electrically Sensing Protease Activity with Nanopores

Kukwikila, M., S. Howorka 

J Physics, 22(45): 454103 (2010)

Chemical Tags Mediate the Self-Assembly of DNA Strands into Supramolecular Structures

Mitchell, N., A. Ebner, P. Hinterdorfer, R. Tampe, S. Howorka 

Small, 6(16): 1732–1735 (2010)

Identifying Assembly-Inhibiting and Assembly-Tolerant Sites in the SbsB S-Layer Protein from Geobacillus stearothermophilus

Kinns, H., H. Badelt-Lichtblau, E.M. Egelseer, U.B. Sleytr, S. Howorka 

J Mol Biol, 395(4): 742-753 (2010)

Engineered Voltage-Responsive Nanopores

Siwy, Z., S. Howorka 

Chem Soc Rev, 39(3): 1115-1132 (2010).

Semipermeable Poly(ethylene glycol) Films: The Relationship between Permeability and Molecular Structure of Polymer Chains

Schlapak, R., D. Caruana, D. Armitage, S. Howorka 

Soft Matter, 5(21): 4104-4112 (2009)

Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates

Borsenberger, V., M. Kukwikila, S. Howorka

Org Biomol Chem, 7(18): 3826-3835 (2009)

Topography and Recognition Imaging of Protein Patterned Surfaces Generated by AFM Nanolithography

Zhu, R. A. Ebner, M. Kastner, J. Preiner, S. Howorka, P. Hinterdorfer 

ChemPhysChem, 10(9-10):1478-81 (2009)

Determination of Free Energy Profiles for the Translocation of Polynucleotides through α-Hemolysin Nanopores using Non-Equilibrium Molecular Dynamics Simulations 

Hugh, M., S. Jha., S. Howorka , P. Coveney 

J Chem Theory Comput, 5(8): 1955-2192. Cover. (2009)

Imaging Surface Charges of Individual Biomolecules 

Leug, C., H. Kinns, B. Hoogenboom , S. Howorka , P. Mesquida 

Nano Lett, 9(7): 2769-2773 (2009)

Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores

Borsenberger, V., N. Mitchell, Howorka, S. 

J Am Chem Soc, 131(22): 7530-7531 (2009)

Nanopore Analytics: Sensing of Single Molecules

Howorka, S., Z. Siwy

Chem Soc Rev, 38(8): 2360-2384 (2009)

Engineering and Exploiting Protein Assemblies in Synthetic Biology

Papapostolou, D., S. Howorka

Mol Biosyst, 5(7): 723-732 (2009)

Receptor Arrays for the Selective and Efficient Capturing of Viral Particles

Pollheimer, P. D., M. Kastner, A. Ebner, D. Blaas, P. Hinterdorfer, H. J. Gruber, S. Howorka 

Bioconjug Chem, 20(3): 466–475 (2009)

Diene-Modified Nucleotides for the Diels-Alder-Mediated Functional Tagging of DNA 

Borsenberger, V., S. Howorka 

Nucleic Acids Res, 37(5): 1477-1485 (2009)

Selective Protein and DNA Adsorption on PLL-PEG Films Modulated by Ionic Strength

Schlapak, R., D. Armitage, N. Saucedo-Zeni, W. Chrzanowski, M. Hohage, D. Caruana, S. Howorka

Soft Matter, 5(3): 613-621. Cover. (2009)

A DNA Nanostructure for the Functional Assembly of Chemical Groups at Tunable Stoichiometry and Defined Nanoscale Geometry

Mitchell, N., R. Schlapak, M. Kastner, D. Armitage, W. Chrzanowski, J. Riener, P. Hinterdorfer, A. Ebner, S. Howorka 

Angew Chem Int Ed, 48(3): 525-7 (2009)

Nanopores: Generation, Engineering and Single-Molecule Applications

Howorka, S., Z. Siwy 

In: Handbook of Single-Molecule Biophysics, Springer (2008)  

Chemical Tags Facilitate the Detection of Individual DNA Strands with Nanopores

Mitchell, N., S. Howorka 

Angew Chem Int Ed, 47(30): 5565-5568. Cover. (2008)

Atomic Force Microscopy-Based Nano-Chip for the Detection of Human Pathogenic Viruses

Artelsmair, H., F. Kienberger, A. Tinazli, R. Schlapak, J. Preiner, J. Wruss, M. Kastner, N. Saucedo-Zeni, M. Hoelzl, C. Rankl, W. Baumgartner, S. Howorka, D. Blaas, H. J. Gruber, R. Tampé, P. Hinterdorfer

Small, 4(6): 847-54 (2008)

The Surface Location of Individual Residues in a Bacterial S-Layer Protein

Kinns, H., S. Howorka 

J Mol Biol, 377(2): 589-604 (2008)

Self-Assembled Monolayers of Protonated Poly(amidoamine) Dendrimers on Indium-Tin-IOxide Electrodes

Latini, G., M. Wykes, R. Schlapak, S. Howorka,  F. Cacialli 

Appl Phys Lett, 92(1): 013511 (2008)

Stochastic Detection of Motor Protein-RNA Complexes by Single-Channel Current Recording 

Astier, Y., D. E. Kainov, H. Bayley, R. Tuma and S. Howorka 

ChemPhysChem 8(15): 2189-2194 (2007)

Creating Regular Arrays of Nanoparticles with Self-Assembling Protein Building Blocks 

Howorka, S. 

J Mater Chem 17(20): 2049-2053. Cover. (2007)

Nanoscale Protein Pores Modified with PAMAM Dendrimers

Martin, H., H. Kinns, N. Mitchell, R. Madathil and S. Howorka 

J Am Chem Soc, 129(31): 9640-9649 (2007)

Dense Passivating Poly(ethylene glycol) Films on Indium Tin Oxide Substrates 

Schlapak, R., D. Armitage, N. Saucedo-Zeni, M. Hohage, S. Howorka

Langmuir,  23(20): 10244-10253 (2007)

Preparation and Characterization of Dense Films of Poly(amidoamine) Dendrimers on Indium Tin Oxide

Schlapak, R., D. Armitage, N. Saucedo-Zeni, G. Latini, H. J. Gruber, Y. Samotskaya, P. Mesquida, F. Cacialli, M. Hohage and S. Howorka 

Langmuir, 23(17): 8916-8924 (2007)

Single-Molecule Microscopy Reveals Heterogeneous Dynamics of Lipid Raft Components upon TCR Engagement 

Drbal, K., M. Moertelmaier, C. Holzhauser, A. Muhammad, E. Fuertbauer, S. Howorka, M. Hinterberger, H. Stockinger and G. J. Schutz 

Int Immunology, 19(5): 675-684 (2007)

Sizing Trinucleotide Repeat Sequences by Single-molecule Analysis of Fluorescence Brightness

Schlapak, R., H. Kinns, C. Wechselberger, J. Hesse and S. Howorka 

ChemPhysChem, 8(11): 1618-1621 (2007)

Glass Surfaces Grafted with High-density Poly(ethylene glycol) as Substrates for DNA Oligonucleotide Microarrays

Schlapak, R., P. Pammer, D. Armitage, R. Zhu, P. Hinterdorfer, M. Vaupel, T. Fruhwirth and S. Howorka

Langmuir, 22(1): 277-285. Featured in Biophotonics International, March 2006. (2006)

RNA Expression Profiling at the Single-molecule Level

Hesse, J., J. Jacak, M. Kasper, G. Regl, T. Eichberger, M. Winklmayr, F. Aberger, M. Sonnleitner, R. Schlapak, S. Howorka, L. Muresan, A. M. Frischauf and G. J. Schutz 

Genome Res, 16(8): 1041-1045. Highlighted in Perspectives section of Genome Research. (2006)

Nanopatterning of Biomolecules with Microscale Beads 

Pammer, P., R. Schlapak, M. Sonnleitner, A. Ebner, R. Zhu, P. Hinterdorfer, O. Höglinger, H. G. Schindler and S. Howorka 

ChemPhysChem, 6(5): 900-903 (2005)

Protein Components for Nanodevices

Astier, Y., H. Bayley and S. Howorka 

Curr Opin Chem Biol, 9(6): 576-584 (2005)

Stochastic Detection of Monovalent and Multivalent Protein-ligand Interactions 

Howorka, S., J. Nam, H. Bayley and D. Kahne

Angew Chem Int Ed Engl, 43(7): 842-846 (2004)

Probing Distance and Electrical Potential within a Protein Pore with Tethered DNA 

Howorka, S. and H. Bayley

Biophys J, 83(6): 3202-3210 (2002)

High-throughput Scanning Mutagenesis by Recombination PCR

Howorka, S. and H. Bayley 

In: In vitro Mutagenesis Protocols, Methods in Molecular Biology. J. Braman. Totowa, NJ, Humana Press: 139-147 (2002)

Location of a Constriction in the Lumen of a Transmembrane Pore by Targeted Covalent Attachment of Polymer Molecules

Movileanu, L., S. Cheley, S. Howorka, O. Braha and H. Bayley 

J Gen Physiol, 117(3): 239-252 (2001)

Sequence-specific Detection of Individual DNA-strands using Engineered Nanopores

Howorka, S., S. Cheley and H. Bayley 

Nat Biotechnol, 19(7): 636-39. Featured in News and Views of issue. (2001)

Kinetics of Duplex Formation for Individual DNA Strands within a Single Protein Nanopore

Howorka, S., L. Movileanu, O. Braha and H. Bayley

Proc Natl Acad Sci U S A, 98(23): 12996-13001 (2001)

A Protein Pore with a Single Polymer Chain Tethered within the Lumen

Howorka, S., L. Movileanu, X. Lu, M. Magnon, S. Cheley, O. Braha and H. Bayley 

J Am Chem Soc, 122(11): 2411-2416. Editors' Choice in Science (2000) 287(5460): 1889-1890. (2000)

Detecting Protein Analytes that Modulate Transmembrane Movement of a Polymer Chain within a Single Protein Pore

Movileanu, L., S. Howorka, O. Braha and H. Bayley 

Nat Biotechnol, 18(10): 1091-1095. Cover and News and Views. Equally contributing co-authorship. (2000)

Surface Accessible Residues in the Monomeric and Assembled Form of a Bacterial Surface Layer Protein

Howorka, S., M. Sára, Y. Wang, B. Kuen, U. B. Sleytr, W. Lubitz and H. Bayley 

J Biol Chem, 48: 37876-37886. Cover. (2000)

Self-assembly Product Formation of the Bacillus Stearothermophilus PV72/p6 S-layer Protein SbsA in the Course of Autolysis of Bacillus subtilis

Howorka, S., M. Sara, W. Lubitz and B. Kuen 

FEMS Microbiol Lett, 172(2): 187-196 (1999)

Improved Protocol for High Through-put Cysteine Scanning Mutagenesis

Howorka, S. and H. Bayley 

BioTechniques, 25(5): 764-772 (1998)

Biotechnological Applications of Recombinant S-layer Proteins rSbsA and rSbsB from B. Stearothermophilus PV72 

Truppe, M., S. Howorka, G. Schroll, S. Lechleitner, S. Resch, B. Kuen and W. Lubitz

(1997) FEMS Microbiol Rev, 20(1-2): 88-98.

2-D Protein Crystals as an Immobilization Matrix for Producing Reaction Zones in Dipstick-style Immunoassays

Breitwieser, A., S. Kupcu, S. Howorka, S. Weigert, C. Langer, K. Hoffmann Sommergruber, O. Scheiner, U. B. Sleytr and M. Sára

BioTechniques, 21(5): 918-925 (1996)